{"id":197,"date":"2020-03-14T17:37:59","date_gmt":"2020-03-14T16:37:59","guid":{"rendered":"http:\/\/www.asso-audrey.org\/?page_id=197"},"modified":"2020-03-14T17:40:30","modified_gmt":"2020-03-14T16:40:30","slug":"les-infections-meningococciques","status":"publish","type":"page","link":"https:\/\/www.asso-audrey.org\/?page_id=197","title":{"rendered":"Les infections m\u00e9ningococciques"},"content":{"rendered":"

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Les infections Invasives m\u00e9ningococciques (m\u00e9ningite et septic\u00e9mie) <\/h3>\n\n\n

Les infections Invasives m\u00e9ningococciques\u00a0(m\u00e9ningite et septic\u00e9mie)<\/b>\u00a0par leur gravit\u00e9 et par la transmissibilit\u00e9 du m\u00e9ningocoque n\u00e9cessitent un diagnostic imm\u00e9diat, des traitements et prophylaxies adapt\u00e9s ainsi qu\u2019un contr\u00f4le du risque \u00e9pid\u00e9miog\u00e8ne. Les infections invasives \u00e0 m\u00e9ningocoque surviennent sous forme de cas sporadiques en France et en Europe.
En France, 800 cas sont r\u00e9pertori\u00e9s par an dont la majorit\u00e9 pendant la saison hivernale. Ces infections frappent essentiellement les enfants et les adolescents. L\u2019OMS estime \u00e0 500.000 cas par an le nombre des cas d\u2019infections invasives \u00e0 m\u00e9ningocoque dans le monde.
\u00a0
Ces infections sont \u00e9pid\u00e9miques en Afrique subsaharienne pendant la saison s\u00e8che (de Janvier \u00e0 Mai). Des dizaines des milliers des cas sont d\u00e9clar\u00e9s par pays.
\u00a0
Les vaccins actuellement disponibles ciblent la capsule bact\u00e9rienne (l\u2019enveloppe qui entoure le m\u00e9ningocoque). Ces vaccins sont donc sp\u00e9cifiques du s\u00e9rogroupe. Il existe des vaccins contre les s\u00e9rogroupes A, C, Y et W135. Il n\u2019existe pas de vaccin contre les m\u00e9ningocoques du s\u00e9rogroupe B. La capsule B est peu immunog\u00e8ne car il est similaire \u00e0 certaines structures sur nos cellules neurales.
\u00a0
Cependant, des avanc\u00e9es sont \u00e0 noter:
\u00a0
– Le d\u00e9veloppement des vaccins recombinants (\u00e0 base de prot\u00e9ines bact\u00e9riennes sous la capsule) est en cours pour cibler les souches du m\u00e9ningocoque B. Cela permet donc de contourner le probl\u00e8me de la capsule B.
\u00a0
– L\u2019introduction d\u2019un nouveau vaccin conjugu\u00e9 contre les souches du s\u00e9rogroupe A (MenAfriVac\u2122) est annonc\u00e9e entre 2009-10 et 2015 en Afrique, pour 250 millions de sujets entre 1 et 29 ans \u00e0 moins de 0,50 dollar la dose avec l\u2019immense espoir d\u2019arr\u00eater les \u00e9pid\u00e9mies dues aux souches du s\u00e9rogroupe A en Afrique subsaharienne.\u00a0
\u00a0
– Le Comit\u00e9 Technique des Vaccinations (CTV) \u00e9value r\u00e9guli\u00e8rement l\u2019utilisation du vaccin conjugu\u00e9 contre le m\u00e9ningocoque du s\u00e9rogroupe C en fonction de l\u2019\u00e9volution des donn\u00e9es \u00e9pid\u00e9miologiques. Cette recommandation d\u2019utilisation varie entre les pays de l\u2019Union Europ\u00e9enne, de l\u2019absence de recommandation, \u00e0 la vaccination cibl\u00e9e ou\u00a0 m\u00eame \u00e0 l\u2019inscription\u00a0 au calendrier vaccinal. En France, ce vaccin est actuellement recommand\u00e9 de fa\u00e7on cibl\u00e9e chez les sujets contacts d\u2019un cas d’infection invasive \u00e0 m\u00e9ningocoque \u00e0 s\u00e9rogroupe C et dans les campagnes \u00e9largies\u00a0 de vaccination pour la pr\u00e9vention des cas group\u00e9s. (Sources Institut Pasteur 02 2009)<\/p>\n\n\n

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